Payyappilly Palakkappilly is an ancient Nasrani family in Kerala, India. It is a Syrian Christian family originally hailing from the ancient Muziris (modern day Paravur Kottakkavu) and spread mainly in central districts of Kerala. Servant of God Mar Varghese Payyappilly Palakkappilly who is the founder of the congregation of the Sisters of the Destitute (S. D.) and Fr. Mathai Payyappilly Palakkappilly who is one of the co-founders of the Vincentian Congregation (V. C.) belong to this noble family.